Van alles m.b.t. Vitamine D

Onderwerpen met wetenschappelijke, medische of algemene gezondheidsgerelateerde informatie en discussie dat niet specifiek betrekking heeft op de ziekte van Lyme.
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vonneke
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Van alles m.b.t. Vitamine D

Berichtdoor vonneke » Za 14 Jun 2008 10:20

Low vitamin D common with rheumatic diseases

PARIS (Reuters Health) - Nearly three quarters of patients seen at a rheumatology clinic, which focuses on diseases affecting the joints, muscles, bones, and tendons, have a vitamin D deficiency, researchers based in Ireland found.

Dr. Muhammad Haroon and associates at South Infirmary-Victoria University Hospital, Cork, assessed the occurrence of vitamin D deficiency in all new patients seen at their rheumatology clinic between January and June 2007. The research team's findings were reported at the European Union League Against Rheumatism 2008 meeting here in Paris.

Of 264 patients seen during this time period, 231 agreed to have their levels of vitamin D measured and other related tests performed

Overall, 162 patients (70 percent) had low vitamin D levels and 26 percent had a severe deficiency. Little difference was seen in the percentage of younger and older patients who were deficient.

Severe vitamin D deficiency affected a significant percentage of patients with a variety of conditions, including inflammatory joint diseases, rheumatism, arthritis, backache, and osteoporosis.

According to Haroon, chronic severe vitamin D deficiency increases the risk of the bone-thinning disease osteoporosis and the bone-softening disease osteomalacia, while a mild-to-moderate deficiency may contribute to non-specific rheumatic complaints, he said.

http://www.reuters.com/article/healthNe ... healthNews

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vonneke
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Re: Van alles m.b.t. Vitamine D

Berichtdoor vonneke » Za 14 Jun 2008 10:24

Vitamin D: its role and uses in immunology

ABSTRACT

In recent years there has been an effort to understand possible noncalcemic roles of vitamin D, including its role in the immune system and, in particular, on T cell-medicated immunity. Vitamin D receptor is found in significant concentrations in the T lymphocyte and macrophage populations. However, its highest concentration is in the immature immune cells of the thymus and the mature CD-8 T lymphocytes. The significant role of vitamin D compounds as selective immunosuppressants is illustrated by their ability to either prevent or markedly suppress animal models of autoimmune disease. Results show that 1,25-dihydroxyvitamin D3 can either prevent or markedly suppress experimental autoimmune encephalomyelitis, rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, and inflammatory bowel disease. In almost every case, the action of the vitamin D hormone requires that the animals be maintained on a normal or high calcium diet. Possible mechanisms of suppression of these autoimmune disorders by the vitamin D hormone have been presented. The vitamin D hormone stimulates transforming growth factor TGFß-1 and interleukin 4 (IL-4) production, which in turn may suppress inflammatory T cell activity. In support of this, the vitamin D hormone is unable to suppress a murine model of the human disease multiple sclerosis in IL-4-deficient mice. The results suggest an important role for vitamin D in autoimmune disorders and provide a fertile and interesting area of research that may yield important new therapies.—DeLuca, H. F., Cantorna, M. T. Vitamin D: its role and uses in immunology

http://www.fasebj.org/cgi/content/full/15/14/2579#top

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vonneke
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Re: Van alles m.b.t. Vitamine D

Berichtdoor vonneke » Do 4 Dec 2008 8:30

http://www.medicinenet.com/script/main/ ... ekey=94623

Too Little Vitamin D Puts Heart at Risk

[quote]Dec. 1, 2008 -- Getting too little vitamin D may be an underappreciated heart disease risk factor that's actually easy to fix.

Researchers say a growing body of evidence suggests that vitamin D deficiency increases the risk of heart disease and is linked to other, well-known heart disease risk factors such as high blood pressure, obesity, and diabetes.

For example, several large studies have shown that people with low vitamin D levels were twice as likely to have a heart attack, stroke, or other heart-related event during follow-up, compared with those with higher vitamin D levels.

"Vitamin D deficiency is an unrecognized, emerging cardiovascular risk factor, which should be screened for and treated," says researcher James H. O'Keefe, MD, director of preventive cardiology at the Mid America Heart Institute in Kansas City, Mo., in a news release. "Vitamin D is easy to assess, and supplementation is simple, safe and inexpensive."

Most of the body's vitamin D requirements are met by the skin in response to sun exposure. Other less potent sources of vitamin D include foods such as salmon, sardines, cod liver oil, and vitamin D-fortified foods like milk and some cereals. Vitamin D can also be obtained through supplements


Vitamin D Deficiency on the Rise
Vitamin D deficiency is traditionally associated with bone and muscle weakness, but in recent years a number of studies have shown that low levels of the vitamin may predispose the body to high blood pressure, congestive heart failure, and chronic blood vessel inflammation (associated with hardening of the arteries). It also alters hormone levels to increase insulin resistance, which raises the risk of diabetes.

In a review article published in the Journal of the American College of Cardiology, researchers surveyed recent studies on the link between vitamin D deficiency and heart disease to come up with practical advice on screening and treatment.

They concluded that vitamin D deficiency is much more common than previously thought, affecting up to half of adults and apparently healthy children in the U.S.

Researchers say higher rates of vitamin D deficiency may be due in part to people spending more time indoors and efforts to minimize sun exposure through the use of sunscreens. Sunscreen with a sun protection factor (SPF) of 15 blocks approximately 99% of vitamin D synthesis by the skin.

"We are outside less than we used to be, and older adults and people who are overweight or obese are less efficient at making vitamin D in response to sunlight," says O'Keefe. "A little bit of sunshine is a good thing, but the use of sunscreen to guard against skin cancer is important if you plan to be outside for more than 15 to 30 minutes of intense sunlight exposure


Testing for Vitamin D Deficiency
Vitamin D levels can be measured with a blood test that looks at a specific form of vitamin D called 25-hydroxy vitamin D (25(OH)D). Vitamin D deficiency is defined as a blood 25(OH)D level below 20 ng/dL. Normal levels are considered to be above 30 ng/dL.

Researchers recommend 25(OH)D screening for those with known risk factors for vitamin D deficiency including:

Older age
Darkly pigmented skin
Reduced sun exposure due to seasonal variation or living far from the equator
Smoking
Obesity
Kidney or liver disease
The U.S. government's current recommended daily allowance (RDA) for vitamin D is 200 international units (IU) per day for individuals under age 50. For those between 50 and 70, 400 IU per day is recommended, and for those over age 70, the RDA is 600 IU. Most experts believe these doses are too low, and that somewhere between 1,000 and 2,000 IU of vitamin D per day is necessary to maintain adequate vitamin D levels. The safe upper limit of vitamin D consumption is 10,000 IU per day.

Vitamin D supplements are available in two different forms: Vitamin D2 and Vitamin D3. Although both appear effective in raising vitamin D blood levels, Vitamin D3 supplements appear to result in a longer-lasting boost.

Although there are no current guidelines for restoring and maintaining healthy vitamin D levels in people at risk for heart disease, for those who are vitamin D deficient, the researchers recommend initial treatment with 50,000 IU of vitamin D2or D3 once a week for eight to 12 weeks, followed by maintenance with one of the following strategies:

[50,000 IU vitamin D2or D3 every 2 weeks
1,000 to 2,000 IU vitamin D3 daily
Sunlight exposure for 10 minutes for white patients (longer for people with increased skin pigmentation) between the hours of 10 a.m. and 3 p.m.
Once maintenance therapy has been initiated, rechecking 25(OH)D blood levels is recommended after three to six months of ongoing supplementation.

"Restoring vitamin D levels to normal is important in maintaining good musculoskeletal health, and it may also improve heart health and prognosis," says O'Keefe. "We need large, randomized, controlled trials to determine whether or not vitamin D supplementation can actually reduce future heart disease and deaths."

SOURCES: Lee, J. Journal of the American College of Cardiology, Dec. 9, 2008; vol 52
/quote]

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vonneke
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Re: Van alles m.b.t. Vitamine D

Berichtdoor vonneke » Zo 14 Dec 2008 21:34

http://www.mayoclinicproceedings.com/pd ... 8103r1.pdf


High Prevalence of Vitamin D Inadequacy and Implications for Health


During the past decade, major advances have been made in
vitamin D research that transcend the simple concept that vitamin
D is important for the prevention of rickets in children and has
little physiologic relevance for adults. Inadequate vitamin D, in
addition to causing rickets, prevents children from attaining their
genetically programmed peak bone mass, contributes to and
exacerbates osteoporosis in adults, and causes the often painful
bone disease osteomalacia. Adequate vitamin D is also important
for proper muscle functioning, and controversial evidence suggests
it may help prevent type 1 diabetes mellitus, hypertension,
and many common cancers. Vitamin D inadequacy has been
reported in approximately 36% of otherwise healthy young adults
and up to 57% of general medicine inpatients in the United States
and in even higher percentages in Europe. Recent epidemiological
data document the high prevalence of vitamin D inadequacy
among elderly patients and especially among patients with osteoporosis.
Factors such as low sunlight exposure, age-related
decreases in cutaneous synthesis, and diets low in vitamin D
contribute to the high prevalence of vitamin D inadequacy. Vitamin
D production from cutaneous synthesis or intake from the few
vitamin D–rich or enriched foods typically occurs only intermittently.
Supplemental doses of vitamin D and sensible sun exposure
could prevent deficiency in most of the general population.
The purposes of this article are to examine the prevalence of
vitamin D inadequacy and to review the potential implications for
skeletal and extraskeletal health.

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vonneke
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Re: Van alles m.b.t. Vitamine D

Berichtdoor vonneke » Za 18 Jul 2009 12:24

Jans schreef:
She urges rigorous scientific studies to clarify the relationship between vitamin D and cardiovascular disease, as well as other chronic diseases.

Misschien kan je het ook omdraaien, is een te laag vitamine D gehalte mogelijk inherent aan een chronische ziekte?
Bij mij is, zodra ik niet meer bijslik, steeds een veel te laag vitamine D gehalte geconstateerd en met het vermoeden dat dit een direct gevolg is van chronische Lyme.



Ik weet het antwoord niet maar er wordt wel steeds meer over Vit. D tekorten geschreven en het schijnt bij allerlei ziekten voor te komen.

Mijn "lymearts" zei wel dat hij geregeld Vit.B12 en Vit. D tekorten ziet bij lymepatiënten.

Debby is vorig week ook getest op Vit. D en krijgt daar aankomende week de uitslag van.

Ik kan me haast niet voorstellen dat ik er een tekort van zou hebben want ik ben dagelijks een paar uur buiten.

Een topic over Lyme en vit. D :

http://www.lymeneteurope.org/forum/view ... 3607#p3607

In de een na laatste reactie daar staat wel :

In adults, new evidence suggests that vitamin D plays a role in the immune system and may help prevent infections



Meer over Vit. D staat ook in het volgende topic :

http://www.lymeneteurope.org/forum/view ... 4519#p4519

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vonneke
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Re: Van alles m.b.t. Vitamine D

Berichtdoor vonneke » Za 15 Aug 2009 20:50

Diegenen die een te lage Vit. D hadden mag ik vragen wat die waarde was ?

Bij ons Lab is allles boven de 30 goed maar onze arts zegt dat er bij Vit. D ook een grijs gebied is net als bij Vit.B 12.

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Lisanne
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Lid geworden op: Di 24 Jul 2007 17:45

Re: Van alles m.b.t. Vitamine D

Berichtdoor Lisanne » Wo 26 Aug 2009 14:30

vonneke schreef:Bij ons Lab is allles boven de 30 goed maar onze arts zegt dat er bij Vit. D ook een grijs gebied is net als bij Vit.B 12.


Hoi Yvonne,

De normaalwaarden voor vitamine D zijn al een tijdje aan herziening onderhevig.

Er zijn twee vormen van vitamine D in het lichaam:
Er is vitamine D als 25(OH)D
en er is de biologisch actieve D: dat is 1,25(OH)2D

Zowel bij 25(OH)D als de 1,25(OH)2D worden door labs en huisartsen soms (of vaak???) nog de ouderwetse, lage normaalwaarden gehanteerd!!..... dus ik vraag aan mijn arts nooit of de gemeten vitamine D "goed" was, maar ik vraag altijd de waarde, met de normaalwaarden erbij (om te kunnen controleren of de herziene (hogere) normaalwaarden of de achterhaalde, lagere waarden zijn/worden gehanteerd).

Een voorbeeld van huidige opvattingen over vitamine D waarden:

De Normaalwaarden 25(OH)D in het Maxima Medisch Centrum (MMC) Eindhoven:

deficiëntie.................. 0 - 12,5 nmol/l
onvoldoende............. 12,5 - 50 nmol/l
hypovitaminose D.... 50 - 100 nmol/l
voldoende...............100 - 250 nmol/l
toxisch..................... >250 nmol/l

De normaalwaarde van vitamine D in de actieve vorm ....
dus 1,25(OH)2D : is (bij MMC): 71-156 picomol per liter (pmol/L)

Groetjes,
Lisanne

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vonneke
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Lid geworden op: Do 16 Jun 2005 20:57

Re: Van alles m.b.t. Vitamine D

Berichtdoor vonneke » Wo 26 Aug 2009 20:30

Bedankt voor je reactie Lisanne.

Bij mijn dochter is dacht op Vit.D3 getest en de waarde was 70. Onze ABNG arts heeft toen Vit. D voorgeschreven.

Groetjes, Yvonne

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vonneke
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Re: Van alles m.b.t. Vitamine D

Berichtdoor vonneke » Wo 26 Aug 2009 20:31

What Is Vitamin D? What Are The Benefits Of Vitamin D? :

http://www.medicalnewstoday.com/articles/161618.php

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Mieke
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Lid geworden op: Do 4 Mei 2006 23:15

Re: Van alles m.b.t. Vitamine D

Berichtdoor Mieke » Wo 26 Aug 2009 22:34

De huisarts zei tegen mij: je vitamine D is weer aan het stijgen het was dit jaar 28, verder zei
hij er niets over, een jaar geleden was het 21.


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