Van alles m.b.t. Vitamine D

[bamboe]

To Your Health
March, 2014 (Vol. 08, Issue 03)
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Vitamin D Over Amoxicillin?

Can a simple supplement such as vitamin D do wonders for your health? According to some new research published in the Lancet Infectious Diseases site, it can help you steer clear of antibiotics.
Two studies in the Lancet looking at respiratory tract infections give credence to Vitamin D over amoxicillin. The first study found that for patients where pneumonia is not suspected, "amoxicillin provides little benefit for acute lower-respiratory-tract infection in primary care both overall and in patients aged 60 years or more, and causes slight harms."

The second study divided a group of adults into two groups: those that took Vitamin D3 (4000 IU) every day for a year and those that were given a placebo. "The overall (respiratory tract) infectious score was significantly reduced for patients allocated to the vitamin D group compared with the placebo group."

These results, when taken together, provide an interesting picture of the potential health through nutrition rather than drugs. Make sure to talk to your doctor about the right way to take supplements and whether or not you need to start taking a vitamin D supplement to improve your overall health.

http://www.toyourhealth.com/mpacms/tyh/ ... hp?id=1947

[Foetsie]

Vitamin D controls T cell antigen receptor signaling and activation of human T cells
Nature Immunology
Marina Rode von Essen, Martin Kongsbak, Peter Schjerling, Klaus Olgaard, Niels Ødum & Carsten Geisler


http://www.nature.com/ni/journal/v11/n4 ... .1851.html

Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-γ1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of ~75-fold in PLC-γ1 expression, which correlated with greater TCR responsiveness. Induction of PLC-γ1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-γ1, which are required for subsequent classical TCR signaling and T cell activation.

(Published online 07 March 2010)