Van alles m.b.t. het hart

Onderwerpen met wetenschappelijke, medische of algemene gezondheidsgerelateerde informatie en discussie dat niet specifiek betrekking heeft op de ziekte van Lyme.
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vonneke
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Lid geworden op: Do 16 Jun 2005 20:57

Re: Van alles m.b.t. het hart

Berichtdoor vonneke » Za 21 Aug 2010 13:25

http://www.medicalnewstoday.com/articles/197628.php

Elevated Heart Rate Over Time Linked To Significant Risk Of Death

An elevated resting heart rate that develops or persists during follow-up is associated with a significantly increased risk of death, whether from heart disease or other causes, researchers from the Ronald O. Perelman Heart Institute at NewYork-Presbyterian Hospital/Weill Cornell Medical Center found studying outcomes in more than 9,000 patients.

The findings, published July 2 online in the European Heart Journal, suggest that tracking heart rate over time can provide a profoundly simple and important marker of health issues that could become lethal but which also might be prevented with diagnosis and treatment

"It is easy and inexpensive to determine heart rate, and in fact is done routinely in a doctor's office. But this study suggests that physicians need to track the pattern over a number of years, not just consider single readings," says the study's lead investigator, Dr. Peter Okin, a noted cardiologist at the Ronald O. Perelman Heart Institute of NewYork-Presbyterian/Weill Cornell and professor of medicine in the Division of Cardiology at Weill Cornell Medical College.

"Based on this study, we believe that an elevated heart rate seen over a number of years is worrisome, signifying that these patients need further evaluation to see what might be causing the high heart rate," he says.

In their study, researchers discovered that development of a heart rate of 84 beats per minute or greater that either developed or persisted in patients during the study's average five-year time span was linked to a 55 percent greater risk of cardiovascular death and a 79 percent greater risk of death from all causes. Although the participants had hypertension, the scientists adjusted for this fact as well as for other cardiovascular risk factors. A healthy heart rate is between 60 and 80 beats per minute.

Even incremental increases in heart rate were associated with increased risk of death. For example, every extra 10 beats per minute higher than a normal resting pulse was associated with a 16 percent increased risk of death from cardiovascular disease and a 25 percent greater risk of all-cause death

This is one of the few studies that has looked at changes in heart rate over time, says Dr. Okin. The notion is that because heart rates may increase or decrease over time in response to changes in a person's condition or response to a treatment, the predictive value of a single heart rate measurement is less valuable than measurements over time.

"Heart rates can change day to day and year to year," he says. "It's like having a higher body temperature one day that goes away the next. Something caused the fever, but it has resolved, perhaps with treatment. Heart rate is the same over a longer time span. If it goes up and remains elevated, some disorder is likely to blame

For example, high heart rate, among other things, is a marker of increased sympathetic nervous system activity, which itself is linked to increased heart ischemia, and is also associated with promoting atherosclerosis and susceptibility to arrhythmia.

This study is a sub-analysis of the LIFE (Losartan Intervention For Endpoint) study, which has been completed. It enrolled 9,193 patients from Scandinavia and the United States to test two different treatments (losartan versus atenolol) for hypertension. Among other variables, heart rate was routinely measured in these patients.

In this study, researchers divided 9,190 patients into two groups those that had a persistent heartbeat rate of 84 or greater per minute, and those that had less. That figure was selected because other studies had suggested it was linked to mortality risk.

After a mean of almost five years, 814 patients (8.9%) died 438 (4.8%) of which from cardiovascular disease. After adjusting for possible effects of randomized treatment, and for every other risk factor (such as age, gender, race, diabetes, history of heart disease, and so on), the researchers found a strong association between persistent elevated heart rate and risk of death.

The patients died from a variety of causes, but considering all factors, "heart rate remains a significant predictor of increased mortality," Dr. Okin says. "In addition to high blood pressure, this study demonstrated that changing heart rate over time is a highly significant predictor of mortality."

To date, no medication has been approved in the United States that can reduce heart rate without side effects, although a drug (ivabradine) is being tested, he says. Exercise and diet have also been shown to lower heart rate

Je zelfbeeld bepaalt vaak de grenzen
van wat je als individu kunt bereiken.


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vonneke
Berichten: 7127
Lid geworden op: Do 16 Jun 2005 20:57

Re: Van alles m.b.t. het hart

Berichtdoor vonneke » Za 21 Aug 2010 13:26

'Thuis hartfilmpje maken met iPhone-achtig apparaat' :

http://www.nu.nl/gezondheid/2315266/thu ... araat.html

Je zelfbeeld bepaalt vaak de grenzen
van wat je als individu kunt bereiken.


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vonneke
Berichten: 7127
Lid geworden op: Do 16 Jun 2005 20:57

Re: Van alles m.b.t. het hart

Berichtdoor vonneke » Za 24 Dec 2011 20:14

http://www.ntvg.nl/publicatie/Geen-verb ... n/volledig

Citeer dit artikel als:Ned Tijdschr Geneeskd. 2011

Geen verband vitamine D-tekort en atriumfibrilleren


Een tekort aan vitamine D is geen risicofactor voor atriumfibrilleren. Dat beschrijft een Amerikaans-Nederlands consortium in American Heart Journal (2011;162:538-41).

Atriumfibrilleren (AF) is de meest voorkomende hartritmestoornis, waarvan nog niet alle risicofactoren in kaart zijn gebracht. Vitamine D-gebrek is lang een verdachte geweest, omdat er vitamine D-receptoren gevonden zijn in verschillende types hartcellen en omdat van het actieve metabole product van vitamine D (1,25-dihydroxyvitamine D) bekend is dat het een sterke bloeddrukregulator is en dat het invloed heeft op ontstekingsreacties.

Om te onderzoeken of vitamine D-tekort inderdaad invloed heeft op atriumfibrilleren, maakten de onderzoekers gebruik van gegevens uit de ‘Original and Offspring Framington Heart Study’, opgezet in 1948. Ze verzamelden serum 25(OH)D-concentratiegegevens van een cohort van 1046 mensen uit 1988-1989 en van 1884 van hun nakomelingen, wiens gegevens verzameld werden in 1996-2001. Vervolgens keken de onderzoekers naar de AF-prevalentie.

De onderzoekers vonden geen enkel significant verband tussen 25(OH)D-concentraties en atriumfibrilleren in beide cohorten. Daaruit blijkt dus dat vitamine D-gebrek geen risicofactor is voor het ontwikkelen van de aandoening.

Je zelfbeeld bepaalt vaak de grenzen
van wat je als individu kunt bereiken.


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