Hier een tekst over hoe je met quercetine de flush blokkeert van de niacine:
De niacinamide (de synthetische non flush variant van de niacine) blijft een alternatief voor de organische nicotinezuur.
Maar die heeft als nadeel de flush die gelukkig te blokkeren valt:
[...]interestingly, a cheap natural alternative appears to trump Cordaptive's putative benefits. A new study appearing in the online edition January 29, 2009 of the British Journal of Pharmacology http://onlinelibrary.wiley.com/doi/10.1 ... 8/abstract
reveals that the supplement quercetin
is a very efficient flush-blocker when teamed with niacin. Quercetin is a common bioflavonoid found in apples, buckwheat, tea and onions
. It is associated with protection from cancer, and blocks the release of histamine from mast cells, making it an ideal allergy blocker.
In the recent study in BJP, rats and humans were given quercetin in doses equivalent to 1000 mg while ingesting niacin. After an average dose of 1750 mg of niacin, quercetin reduced flushing by a whopping 96%! By comparison, aspirin (even at 325 mg) only reduced the flushing by 30%.
In the experiment, quercetin was injected into experimental subjects, so it remains to be seen if oral dosing of quercetin will confer the same benefits, but it certainly is inexpensive and natural, and worth a try if you're taking niacin and are bothered by flushing. Because more quercetin is absorbed via injection than by the oral route, I would recommend two 500 mg capsules of quercetin two or three times daily an hour or so before niacin dosing.
Niacine flushing en depressie tegengaan: http://www.youtube.com/watch?NR=1&featu ... qOCRzkhZu4
Als je lichaam te weinig niacine heeft, gaat het het aminozuur tryptofaan gebruiken om zelf niacine aan te maken: maar tryptofaan wordt ook gebruikt voor de serotonine-aanmaak en die krijgt er dan onder te lijden.
Boekentip: The Ultimate Guide to Niacin Flush van Sophie van de Voorde.
While improvements in lipid profiles are meaningful to physicians, patients may be more willing to tolerate the transient flushing symptoms that can occur if they realise that niacin reduces cardiovascular risk, as determined by both mortality and cardiovascular event rates, and that this benefit extends beyond the duration of active therapy. The importance of continuing to take the final daily maintenance dose of niacin extended-release should be emphasised. If there is a period of discontinuation, the titration procedure has to be followed again, although it maybe possible to accelerate it at the discretion of the prescriber. Patients are [...] advised to avoid hot beverages, spicy foods and hot showers near the time of taking niacin. Given niacin’s beneficial effects across a wide spectrum of the lipid profile, [...] it should be regarded as an attractive option for the treatment of dyslipidaemia.