Is Bartonella overdraagbaar in de zwangerschap?

[Danger]

Hallo,

Ik heb het stuk Co-infecties bij de ziekte van Lyme over Bartonella gelezen op www.borreliose.nl.
Ik vind het aannemelijk dat ik deze co-infectie ook heb, aangezien de verschijnselen die hierbij voorkomen en mijn bloeduitslag die voor IgG hoger dan 1:64 is.

Nu is mijn vraag of deze ziekte via de zwangerschap overdraagbaar is?

[RobertF]

Volgens deze studie bij katten is het niet overdraagbaar

Five female specific pathogen-free (SPF) cats inoculated intradermally with B. henselae and bacteremic for 4 weeks, and one cat inoculated with 0.9% NaCl, were bred with uninfected SPF male cats. The uninfected female became pregnant with one breeding, while three infected cats became pregnant 1-12 weeks later, after repeated breedings. Two infected females either did not become pregnant or maintain pregnancies despite repeated breedings. Infected cats produced anti-B. henselae IgM and IgG antibodies. Fetuses and kittens of infected cats were not infected and did not produce anti-B. henselae antibodies. Male cats bred with infected females did not become infected or seroconvert. Maternal anti-B. henselae IgG antibodies detected in sera of kittens 2 weeks post-partum were no longer detectable 10 weeks post-partum. These findings suggest that B. henselae causes reproductive failure in female cats, but is not transmitted transplacentally, in colostrum or milk, or venereally. Infected cats immunosuppressed with methylprednisolone acetate after their kittens were weaned had no detectable bacteria in tissues, suggesting that they were no longer infected

[RobertF]

Volgens deze studie bij knaagdieren wel

Embryos and neonatal offspring of wild-captured cotton rats (Sigmodon hispidus) and white-footed mice (Peromyscus leucopus) were tested for the presence of Bartonella spp. Isolates of Bartonella spp. were obtained from 18 of 31 embryos and 7 of 19 neonates from bacteremic dams of the two species; no isolates were obtained from material from non-bacteremic dams. Sequence analysis demonstrated that the isolates from embryos and neonates matched the phylogenetic group of Bartonella spp. isolates obtained from the mother. No antibodies to homologous Bartonella spp. antigens were detected in maternal and neonatal blood or embryonic tissue. These findings suggest the possibility of vertical transmission of Bartonella spp. among natural rodent hosts.

[Martijn]

Ik vind het aannemelijk dat ik deze co-infectie ook heb, aangezien de verschijnselen die hierbij voorkomen en mijn bloeduitslag die voor IgG hoger dan 1:64 is.

Ik denk dat de testuitslag een beperkte waarde heeft. In een recente publicatie staat: "The high seroprevalence in healthy individuals limits the clinical value of IgG detection for diagnosing CSD."

Aangezien je katten hebt, is het goed mogelijk dat je één of meerdere keren door een kattenkrab of -beet bent geïnfecteerd met Bartonella.

[Danger]

Aangezien je katten hebt, is het goed mogelijk dat je één of meerdere keren door een kattenkrab of -beet bent geïnfecteerd met Bartonella.

Ja, dat zou idd kunnen. Ik ben vaak genoeg gebeten en gekrabd in mijn leven.
En ik heb een tekenbeet en EM gehad.
Dus kan beide.
Daarbij schreef ik dat ik het aannemelijk vind dat ik bartonella heb, niet dat ik het zeker heb.
Mijn arts zegt dat ik het doorgemaakt heb en nu niet meer heb, maar dat wordt ook vaak bij Lyme gezegd, zoals we weten.
Ik zou niet weten of ik nu nog last heb van bartonella of daar ooit last van heb gehad.

Mijn zoontje heb ik overigens niet laten testen voor bartonella.

Zou dat overigens wat uitmaken, waardoor je de bartonella hebt gekregen?
Zou dit dezelfde uitwerking op de bb hebben?

[vonneke]

Danger schreef :

Nu is mijn vraag of deze ziekte via de zwangerschap overdraagbaar is?

Er is nu moleculair bewijs van perinatale transmissie van Bartonella vinsonii subsp. berkhoffii en B. henselae



http://jcm.asm.org/cgi/content/abstract ... type=HWCIT

Molecular evidence of perinatal transmission of Bartonella vinsonii subsp. berkhoffii and B. henselae to a child

Abstract

Bartonella vinsonii subsp. berkhoffii, Bartonella henselae or DNA of both organisms was amplified and sequenced from blood, enrichment blood cultures or autopsy tissues from four family members. Historical and microbiological results support perinatal transmission of Bartonella species in this family.

http://news.ncsu.edu/uncategorized/bartonella/

Disease Caused By Insect Bites Can Be Transmitted To Children At Birth, NC State Researcher Finds

A North Carolina State University researcher has discovered that bacteria transmitted by fleas–and potentially ticks–can be passed to human babies by the mother, causing chronic infections and raising the possibility of bacterially induced birth defects

Dr. Ed Breitschwerdt, professor of internal medicine in the Department of Clinical Sciences, is among the world’s leading experts on Bartonella, a bacteria that is maintained in nature by fleas, ticks and other biting insects, but which can be transmitted by infected cats and dogs as well. The most commonly known Bartonella-related illness is cat scratch disease, caused by B. henselae, a strain of Bartonella that can be carried in a cat’s blood for months to years. Cat scratch disease was thought to be a self-limiting, or “one-time” infection; however, Breitschwerdt’s previous work discovered cases of children and adults with chronic, blood-borne Bartonella infections–from strains of the bacteria that are most often transmitted to cats (B. henselae) and dogs (B. vinsonii subsp. berkhoffii) by fleas and other insects.

In his most recent case study, Breitschwerdt’s research group tested blood and tissue samples taken over a period of years from a mother, father and son who had suffered chronic illnesses for over a decade. Autopsy samples from their daughter–the son’s twin who died shortly after birth–contained DNA evidence of B. henselae and B. vinsonii subsp. berkhoffi infection, which was also found in the other members of the family.

Both parents had suffered recurring neurological symptoms including headaches and memory loss, as well as shortness of breath, muscle weakness and fatigue before the children were born. In addition, their 10-year-old son was chronically ill from birth and their daughter died due to a heart defect at nine days of age.

Results of the parents’ medical histories and the microbiological tests indicated that the parents had been exposed to Bartonella prior to the birth of the twins, and finding the same bacteria in both children, one shortly after birth and the other 10 years later, indicates that they may have become infected while in utero.

Breitschwerdt’s research appears online in the April 14 Journal of Clinical Microbiology.

“This is yet more evidence that Bartonella bacteria cause chronic intravascular infections in people with otherwise normal immune systems, infections that can span a decade or more,” Breitschwerdt says. “Also this new evidence supports the potential of trans-placental infection and raises the possibility that maternal infection with these bacteria might also cause birth defects.”

The Department of Clinical Sciences is part of NC State’s College of Veterinary Medicine. Dr. Breitschwerdt is also an adjunct professor of medicine at Duke University Medical Center