Detection of borreliae in the placenta of two patients with erythema migrans
J. Hercogováa, J. ivnýa and D. Janovskáa
a Charles University Prague Czech Republic
1 Institute of National Health Prague Czech Republic
Available online 20 March 2000.
Objective: To study a possible intrauterine Borrelia infection in 31 women treated for erythema migrans (EM).
Results: 29 pts. delivered healthy children. In one pt. who delivered a healthy child the remains of Borrelia antigens were detected by MoAb against OspA (H 5332) in the ultrathin sections of the placenta. Two pts. had abnormal outcomes: In the first one, an intrauterine fetal death was found out in 15th week and Borrelia-like organism was detected in ultrathin sections of the decidua, incl. positive staining with MoAb H 9724 against flagellin. Abortus in the second pt. was induced for malformations, but Borrelia evidence was unsuccessful.
Conclusions: Borrelia-like organism detected in the placenta of pt. with EM started in the 1st trimester could influence the fetus and cause abortion. However, Borrelia antigens detected in the placenta of pt. with EM started in the 2nd trimester have not influenced the fetus and a healthy child was delivered in term. Further studies on Lyme borreliosis during pregnancy are to be done.
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