Lymfadenopathie:Lyme -Sarcoïdose -Cat scratch disease–Vit.D

Wetenschappelijke onderwerpen die betrekking hebben op de ziekte van Lyme, zoals wetenschappelijke medische publicaties en artikelen die worden ondersteund door dergelijke publicaties.
Gebruikersavatar
Diesel
Berichten: 224
Lid geworden op: Za 11 Mei 2013 11:52

Lymfadenopathie:Lyme -Sarcoïdose -Cat scratch disease–Vit.D

Berichtdoor Diesel » Za 7 Sep 2013 13:37

Lymfadenopathie: Lyme – Sarcoïdose – Cat scratch disease – Vit.D 1,25

Lymfadenopathie is een verzamelnaam voor een aandoening van de lymfklieren. Het opzwellen van de lymfklieren kan worden veroorzaakt door een hele reeks aandoeningen. Lymfklieren raken meestal opgezet door een bacteriële of virale infectie.

January 2010 Clinical Laboratory News: Lyme Disease

http://www.aacc.org/publications/cln/20 ... Jan10.aspx

Clinical Manifestations

Erythema migrans is usually asymptomatic but may be pruritic or painful. It also may be accompanied by systemic findings such as fever, malaise, headache, regional lymphadenopathy, stiff neck, myalgia, or arthralgia.

LYME DISEASE

http://www.uveitis.org/docs/dm/lyme_disease.pdf

Lijing Yao, MD

CLINICAL FEATURES

Stage I begins within 1 month of an infected tick bite, usually in the summer, and is manifested by an oval or annular skin rash of varying severity, often with a clear center at the area of the bite: erythema migrans (Picture 1).17-19 The lesion may itch or be painful, but is often asymptomatic. Only approximately 30% of persons may recall being bitten. Other symptoms including headache, malaise, fatigue, fever, and arthralgias; lymphadenopathy may also occur at the early stage.

Stage III may occur up to 2 years after the initial infection and is characterized by prolonged episodes of migratory oligoarthritis and chronic neurologic syndromes.17Neurological features include ataxia, chronic encephalopathy, seizure, dementia, myelitis, spastic paraparesis, and psychiatric disturbances. Other symptoms include fatigue, lymphadenopathy, splenomegaly, sore throat, dry cough, nephritis, hepatitis, or orchitis.17,18

Diagnosis

Lyme disease is a disorder with multiple organ involvement. Therefore, the diagnosis must always be considered in diseases that have multiorgan system involvement with constitutional, arthritic, neurologic, and ocular symptoms. Systemic diseases, such as syphilis, tuberculosis, and sarcoidosis, are the major disorders that should be ruled out in the differential diagnosis of Lyme disease.

Clinical Mimics of Lymphoma

http://theoncologist.alphamedpress.org/ ... 4/406.long

Lymphadenopathy is a common clinical finding and is frequently benign.

Benign etiologies of lymphadenopathy can include infections, autoimmune disorders, drug hypersensitivity reactions, sarcoidosis, and amyloidosis.

A variety of other benign conditions is associated with lymphadenopathy. Sarcoidosis requires particular mention since it can quite easily mimic lymphoma with diffuse lymphadenopathy

Lymphadenopathy

http://hab.hrsa.gov/deliverhivaidscare/ ... pathy.html

Infectious Causes

Generalized lymphadenopathy

• HIV infection, including PGL
• Mononucleosis; Epstein-Barr virus
• Mycobacterium avium complex
• TB
• Cytomegalovirus
• Secondary syphilis
• Toxoplasmosis
• Histoplasmosis, other fungal diseases
Bartonella infection
• Hepatitis B
Lyme disease
• Widespread skin infections
• IRIS involving various infections
• Follicular hyperplasia
• Castleman disease

Other Causes

• Reactive process (benign)
Sarcoidosis
• Hypersensitivity reaction to medications
• Serum sickness
• Rheumatoid arthritis

Diagnostic Evaluation

• Blood cultures, if patient is febrile (bacterial, mycobacterial, and fungal, as indicated)
• Testing for specific infections if suspected (e.g., Bartonella, LGV)

Cat scratch disease in Greece.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1717431/

An indirect fluorescent antibody test for Bartonella henselae, B quintana, and B elizabethae was performed in all 18 children who presented to our paediatric outpatient clinic with cat scratch disease over a six year period. Serum samples were taken on admission, after 15 days, and after six months. Diagnosis was confirmed in 15 patients (83%) and was based on seroconversion or a fourfold change of the antibody titre to B henselae in 12 patients and on a single high titre (> 128) in three patients. Lymphadenopathy was present in all patients, erythema nodosum in one, osteomyelitis in one, hepatitis in one, transverse myelitis in one, and liver or spleen granulomata, or both, in three patients. Cat scratch disease developed in autumn or winter in 12 patients. All had a history of physical contact with a cat. Our study shows that our clinical suspicion was accurate in the diagnosis of cat scratch disease in a high percentage of patients presenting to a hospital and that indirect fluorescent antibody testing for B henselae is a useful diagnostic tool.

Nog een bruikbare test is de Vit.D 1,25-dihydroxy bij zowel: Lymfadenopatie, Cat- scratch disease, Lyme, Sarcoidose, Candidiasis, Rickettsiosen en Epstein-Barr virus etc.

Bij granolomateuze ziekten o.a. Sarcoïdose, IBD: ziekte van Crohn (ook wel Sarcoïdose van de darm genoemd) en TBC (Tuberculose), Cat- Scratch disease, Lymfadenopathie, vindt 1 alpha hydrolase plaats in de macrofagen. Dit wel zeggen er vindt omzetting van de niet actieve 25D (calcidiol) naar het actieve hormoon 1,25D (calcitriol) plaats in de macrofagen, in de infectie haarden.

Chronic Lyme Disease and co-infections: Differential Diagnosis

http://www.benthamscience.com/open/tone ... TONEUJ.pdf

Table 10. Disease Manifestations of Chronic Lyme Disease and Chronic Co-infections (Overview)

Disease .......... Symptomatology
Lyme disease ........ LA .. +
Bartonellosis ........ LA .. +

LA = lymphadenopathy

Parotid swelling, phlegmonous abcess in the neck region, septic shock, thrombocytopenic purpura, overproduction of calcitriol

(calcitriol = Vit.D 1,25-dihydroxy)

Vitamin D in Defense of the Human Immune Response

http://www.vdveldehuisarts.nl/sites/def ... 202007.pdf

Tabel 3. Granuloma vormende ziektes waarbij ongereguleerde
synthese van 1,25(OH)2D kan optreden met bijbehorende hypercalcemie en hypercalcurie.

TABLE 3. Human granuloma-forming diseases reported to be complicated by 1,25-
dihydroxyvitamin D-driven hypercalcemia or hypercalciuria


Noninfectious .............. Infectious .............. Neoplastic
Sarcoidosis .............. Tuberculosis ......... B cell lymphoma
Crohn’s disease ........... Leprosy ......... Hodgkin’s disease
Silicone granulomata ... Candidiasis ... .. Lymphomatoid granulomata
Paraffin granulomata ... Histoplasmosis .... Dysgerminorma
Berylliosis ................. Coccidiomycosis ..... Seminoma
Wegener’s infantile fat ... Cat scratch fever ... Mesothelioma
necrosis slack skin disease

Lymphomatoid Granulomatosis

http://emedicine.medscape.com/article/299751-overview

Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus –associated systemic angiodestructive lymphoproliferative disease.

Lymphomatoid granulomatosis. Evidence of immunophenotypic diversity and relationship to Epstein-Barr virus infection.

http://www.ncbi.nlm.nih.gov/pubmed/7573693

Koorts, uitslag en lymfadenopathie na terugkeer uit Sub-Saharisch Afrika: diagnose en behandeling van rickettsiosen uit de "spotted fever"-groep

https://lirias.kuleuven.be/handle/123456789/411651

In het verlengde hiervan, aanvullend van karakter, gelet op de prevalentie lymfadenopathie, indien van toepassing Co infectie (Bartonella henselae), EBV etc. bij Lyme patiënten is de Vit.D 1,25-dihydroxy gewenst, dan wel noodzakelijk.

Diesel
''Hij is wijs, die weet, dat hij niets weet''

My weblog tells you more about Vit.B12 deficiency

Foetsie
Berichten: 1515
Lid geworden op: Ma 24 Dec 2012 17:00

Re: Lymfadenopathie:Lyme -Sarcoïdose -Cat scratch disease–Vi

Berichtdoor Foetsie » Ma 9 Sep 2013 21:19

Vooral de link over kattekrab ziekte heb ik uitgebreid gelezen.
Cat scratch disease in Greece.


M.n. de referenties maar daar ben ik nog wel eventjes mee bezig.

Gebruikersavatar
Diesel
Berichten: 224
Lid geworden op: Za 11 Mei 2013 11:52

Re: Lymfadenopathie:Lyme -Sarcoïdose -Cat scratch disease–Vi

Berichtdoor Diesel » Za 28 Sep 2013 11:43

Bartonella and Brucella−−Weapons and Strategies for Stealth Attack

http://perspectivesinmedicine.cshlp.org ... 1.full.pdf

When incidentally transmitted to humans, Bartonella and Brucella cause chronic infections that are frequently misdiagnosed, misreported, and therefore underestimated (Schwartzman 1996; Velho et al. 2003; Pappas et al. 2006). Human bartonellosis ranges from the benign self-limiting manifestation of cat scratch disease (CSD) caused by infection with Bartonella henselae and possibly Bartonella clarridgeiae (Kordick et al. 1997), to a devastating hemolytic anemia caused by B. bacilliformis. B. henselae spreads in the feline reservoir by cat fleas (Ctenocephalides felis) (Chomel et al. 1996)and is transmitted to humans probably via inoculation of contaminated flea feces during a cats cratch or bite (Chomel et al. 2009). Symptoms of CSD are mainly lymphadenopathy (lymphnode swelling) and occasionally fatigue and fever (Lamps and Scott 2004). B. quintana causes trench fever, a disease with persistent bacteremia that spreads under poor hygiene conditions by body lice (Pediculus humanus corporis) and oc- casionally by cat fleas (Rolain et al. 2003).

Symptoms of the acute phase of human brucellosis are flu-like periodic fevers with muscle and joint pain followed by lymphadenopathy, hepatosplenomegaly, and development of granulomas at multiple sites of the body (Franco et al. 2007a).

Met uitgebreid overzicht diverse Bartonella en Brucella soorten (pag 3)

Diesel
''Hij is wijs, die weet, dat hij niets weet''

My weblog tells you more about Vit.B12 deficiency

Gebruikersavatar
Diesel
Berichten: 224
Lid geworden op: Za 11 Mei 2013 11:52

Re: Lymfadenopathie:Lyme -Sarcoïdose -Cat scratch disease–Vi

Berichtdoor Diesel » Vr 4 Okt 2013 21:41

Beyond Cat Scratch Disease: A Case Report of Bartonella Infection Mimicking Vasculitic Disorder


http://www.hindawi.com/crim/infectious. ... 12/354625/

Cat scratch disease (CSD) is a bacterial disease caused by Bartonella henselae. It is mainly characterized by self-limiting lymphadenopathy (especially around the head, neck, and upper limbs) in the draining site of a cat scratch or bite.

Diesel
''Hij is wijs, die weet, dat hij niets weet''

My weblog tells you more about Vit.B12 deficiency

Gebruikersavatar
Diesel
Berichten: 224
Lid geworden op: Za 11 Mei 2013 11:52

Re: Lymfadenopathie:Lyme -Sarcoïdose -Cat scratch disease–Vi

Berichtdoor Diesel » Za 12 Okt 2013 12:03

Transverse Myelitis Associated with Probable Cat-Scratch Disease in a Previously Healthy Pediatric Patient

http://cid.oxfordjournals.org/content/31/2/609.long

We evaluated a pediatric patient for transverse myelitis associated with Bartonella henselae infection.

Cat-scratch disease is caused by the organism Bartonella henselae and is classically described as self-limited regional lymphadenitis.

We recently evaluated a patient who developed transverse myelitis associated with probable B. henselae infection. A case of transverse myelitis as a CNS complication of cat-scratch disease was described in an adult patient before the development of specific serology to confirm infection [2]. Our case demonstrates this entity in a pediatric patient in the era of serology-based diagnosis of the disease.

His parents denied periods of altered mental status, and he denied headache, blurred vision, or hearing loss. His parents also denied recent travel, skin rash, tick bite, fever, cough, nausea, vomiting, diarrhea, ill contacts, or recent viral illness.

A working diagnosis of transverse myelitis was formulated. Additional diagnostic tests were negative, including serologies for hepatitis, Epstein-Barr virus, Lyme disease, and mycoplasma.

Cat-scratch disease usually presents as subacute regional lymphadenopathy, and causation is determined with serological testing for B. henselae.

Regional lymphadenopathy from the primary inoculation site is the rule even in atypical disease, but it is not universally present.

It is accepted that, in immunocompromised patients with disseminated disease, improvement is seen with antibiotic treatment [8]. Azithromycin has been found to hasten the resolution of typical cat-scratch disease, particularly in regard to total decrease in lymph node volume [9], but there are no controlled studies of treatment benefit in atypical disease.

Diesel
''Hij is wijs, die weet, dat hij niets weet''

My weblog tells you more about Vit.B12 deficiency

Gebruikersavatar
Diesel
Berichten: 224
Lid geworden op: Za 11 Mei 2013 11:52

Re: Lymfadenopathie:Lyme -Sarcoïdose -Cat scratch disease–Vi

Berichtdoor Diesel » Za 26 Okt 2013 12:33

Benign lymphoproliferative disorders.

http://www.ncbi.nlm.nih.gov/pubmed/8650440

Department of Nursing, University of Kansas Medical Center, Kansas City 66018, USA.

OBJECTIVE:
To provide a review of three benign lymphoproliferative disorders commonly encountered in nursing practice: (1) infectious mononucleosis, (2) cat scratch disease, and (3) sarcoidosis.

DATA SOURCES:
Research studies, review articles, and book chapters pertaining to benign lymphoproliferative disorders.

CONCLUSIONS:
Benign lymphoproliferative disorders may be associated with infections, autoimmune disorders, hypersensitivity reactions, and unknown causes. Most of these disorders are self-limiting; however, some are associated with significant morbidity and mortality.

IMPLICATIONS FOR NURSING PRACTICE:
Benign as well as malignant lymphoproliferative disorders will be encountered with increasing frequency by nurses in ambulatory settings. Nurses need to have a basic knowledge of these disorders that present a diagnostic and management challenge.

Diesel
''Hij is wijs, die weet, dat hij niets weet''

My weblog tells you more about Vit.B12 deficiency

Gebruikersavatar
Diesel
Berichten: 224
Lid geworden op: Za 11 Mei 2013 11:52

Re: Lymfadenopathie:Lyme -Sarcoïdose -Cat scratch disease–Vi

Berichtdoor Diesel » Za 9 Nov 2013 13:01

Lymphadenopathy and systemic lupus erythematosus

http://www.scielo.br/pdf/rbr/v50n1/en_v50n1a10.pdf

Table 1
Differential diagnosis of lymphadenopathy

Infections
Cytomegalovirus, Epstein-Barr virus, Hiv, Toxoplasmosis, Tuberculosis

Drugs
Captopril, Penicillamine, Hydralazine, Phenytoin, Gold salts

Inflammatory diseases
Sarcoidosis, Still’s Disease, SLE, Rheumatoid Arthritis, Kikuchi-Fujimoto disease

Neoplasia
Lymphoma

Diesel
''Hij is wijs, die weet, dat hij niets weet''

My weblog tells you more about Vit.B12 deficiency

Gebruikersavatar
Diesel
Berichten: 224
Lid geworden op: Za 11 Mei 2013 11:52

Re: Lymfadenopathie:Lyme -Sarcoïdose -Cat scratch disease–Vi

Berichtdoor Diesel » Do 14 Nov 2013 13:00

Dispelling the Chronic Lyme Disease Myth

http://www.minnesotamedicine.com/Defaul ... tabid=2638

Diagnosing and Treating Lyme Disease

Early localized Lyme disease arises within 3 to 30 days after being bitten by an infected blacklegged tick. It typically, but not always, manifests as a characteristic erythema migrans (EM) rash at the site of the bite. Regional lymphadenopathy with or without fever may be seen as well.

Diesel
''Hij is wijs, die weet, dat hij niets weet''

My weblog tells you more about Vit.B12 deficiency


Terug naar “Wetenschap”

Wie is er online

Gebruikers op dit forum: Common Crawl [ Bot] en 2 gasten